Research in mice suggests additional role for sirtuins By Tina Hesman Saey Web edition : Monday, July 12th, 2010 Text Size
Aging and wisdom are supposed to go together, but it turns out that a molecule that prevents one may actually play a role in the other.
Researchers have discovered a new role for the famous antiaging protein SIRT1. It not only fends off aging, but also aids in learning and memory, a new study published online July 11 in Nature shows.
Sirtuins, a family of proteins that includes SIRT1, help to regulate gene activity and have been implicated in governing metabolism and many of the biological processes that lead to aging. In the new study, Li-Huei Tsai, a neuroscientist and Howard Hughes Medical Institute investigator at MIT, finds that SIRT1 also plays a critical role in protecting learning and memory, at least in mice.
Tsai and her colleagues had an inkling that SIRT1 might play some role in the brain from earlier experiments showing that resveratrol, an activator of sirtuins, could help neurons survive a mouse version of Alzheimer’s disease. Resveratrol also improved the animals’ ability to learn and remember. Since resveratrol can act on all seven of the sirtuins found in mammals and also affects other biological processes (SN Online: 6/28/10), the researchers didn’t know what role, if any, SIRT1 played in the process.
Visit us at http://www.icareforyouhomecare.com if you need home care in Charlotte, N.C..
I Care For You Home Care, L.L.C.
1(800) 383-0520
